Oral Manifestations in Patients with Rheumatoid Arthritis in the Rheumatology Clinic in Southeast Iran
DOI:
https://doi.org/10.22100/ijhs.v10i2.1115Keywords:
Oral manifestations, Rheumatoid Arthritis, Non-probability convenience samplingAbstract
Background: Rheumatoid Arthritis (RA) as an autoimmune disease involving joints can cause oral manifestations in patients. This study aimed to investigate the prevalence of oral manifestations in patients with RA referred to the rheumatology clinic of Zahedan University of Medical Sciences in 2022.
Methods: The present study was a descriptive cross-sectional observational study and included all patients with RA who were referred to Imam Ali Hospital, Zahedan Rheumatology Clinic for treatment in 2022. The method was non-probability convenience sampling and the obtained information was recorded in the information form made by the researcher. After collecting the data, the raw data was entered into the statistical software SPSS version 24 and analyzed using t-test and Fisher's exact test.
Results: According to the findings of the present study, there is no significant difference between the frequency of oral manifestations of 55 patients with RA referred to the rheumatology clinic of Zahedan University of Medical Sciences in the two groups of men and women (Pvalue=0.50). Also, the average age of people in the two groups of patients with oral manifestations and patients without oral manifestations is not statistically significant (Pvalue=0.50). The frequency distribution of oral manifestations of patients with RA showed that xerostomia was the most frequent among oral manifestations.
Conclusions: It seems that the frequency of oral mucosal lesions in people with RA is high and their importance can be emphasized as a possible complication of the disease.
References
Lampa J. Studies of pharmacological interventions and pathogenesis of rheumatoid arthritis: Institutionen för medicin/Department of Medicine; 2002.
Gulati M, Farah Z, Mouyis M. Clinical features of rheumatoid arthritis. Medicine. 2018;46(4):211-5. doi: 10.1016/j.mpmed.2018.01.008
Finckh A, Gilbert B, Hodkinson B, Bae S-C, Thomas R, Deane KD, et al. Global epidemiology of rheumatoid arthritis. Nature Reviews Rheumatology. 2022;18(10):591-602. doi: 10.1038/s41584-022-00827-y
Scherer HU, Häupl T, Burmester GR. The etiology of rheumatoid arthritis. Journal of autoimmunity. 2020;110:102400. doi: 10.1016/j.jaut.2019.102400
Bogale Z, Feleke Y. Prevalence, Clinical Manifestations, and Treatment Pattern of Patients with Rheumatoid Arthritis Attending the Rheumatology Clinic at Tikur Anbessa Specialized Hospital, Ethiopia: A Cross-Sectional Study. Open Access Rheumatology: Research and Reviews. 2022:221-9. doi: 10.2147/OARRR.S383778
Parvaei P, Dorri-giv A, Sharifzadeh G, Malakimoghadam H, Atabati E. Oral mucosal lesions and dmft index assessment in rheumatoid arthritis patients in birjand, iran, in 2018. The Open Rheumatology Journal. 2020;14(1). doi: 10.2174/1874312902014010034
Parsaei A, Mehdipour A, Ghadimi H, Mohammadi Kooshki A, Shajari P, Masoumi M, et al. Oral health-related quality of life in rheumatoid arthritis: a comparative analysis. BMC rheumatology. 2022;6(1):61. doi: 10.1186/s41927-022-00292-w
Marino S, Woo S-B, Gualtierotti R, Buchanan JA, Shandu S, Spadari F, et al. Oral Manifestations Associated with Rheumatic Diseases. A Clinician's Pearls & Myths in Rheumatology: Springer; 2023. p. 369-93. doi: 10.1007/978-3-031-23488-0_24
Yuan A, Woo S-B. Adverse drug events in the oral cavity. Oral surgery, oral medicine, oral pathology and oral radiology. 2015;119(1):35-47. doi: 10.1016/j.oooo.2014.09.009
Cordeiro PC, Guimaraes JP, de Souza VA, Dias IM, Silva JN, Devito KL, et al. Temporomandibular joint involvement in rheumatoid arthritis patients: association between clinical and tomographic data. Acta odontologica latinoamericana : AOL. 2016 Dec;29(3):123-9.
Pedrazas CH, Azevedo MN, Torres SR. Oral events related to low-dose methotrexate in rheumatoid arthritis patients. Brazilian oral research. 2010 Jul-Sep;24(3):368-73. doi: 10.1590/S1806-83242010000300018
Aliko A, Alushi A, Tafaj A, Lela F. Oral mucosa involvement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. International dental journal. 2010 Oct;60(5):353-8.
Mandana K, Seyed Reza N, Sina S, Nahid Moezzi G. The prevalence of oral mucosal lesions and associated factors in 385 patients with rheumatoid arthritis in rheumatology clinics of Tehran University for a period of one year. Pajoohandeh. 2014;19(2):112-8.
Meyer U, Kleinheinz J, Handschel J, Kruse-Lösler B, Weingart D, Joos U. Oral findings in three different groups of immunocompromised patients. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2000 Apr;29(4):153-8. doi: 10.1034/j.1600-0714.2000.290402.x
Parvaei P, Dorri-giv A, Sharifzadeh G, Malakimoghadam H, Atabati E. Oral Mucosal Lesions and DMFT Index Assessment in Rheumatoid Arthritis Patients in Birjand, Iran, in 2018. The Open Rheumatology Journal. 2020 11/25;14:34-9. doi: 10.2174/1874312902014010034
Geterud A, Bake B, Bjelle A, Jonsson R, Sandberg N, Ejnell H. Swallowing problems in rheumatoid arthritis. Acta oto-laryngologica. 1991;111(6):1153-61. doi: 10.3109/00016489109100771
Alahmed A, Abdulkareem K, Zaidan T, Yahya A, al Ahmed A. Correlation Between the Oral Manifestations of Rheumatoid Arthritis Patients on Different Treatments with The Clinical Disease Activity. IOSR Journal of Dental and Medical Sciences. 2016 09/01;15. doi: 10.9790/0853-150905132138
Mays JW, Sarmadi M, Moutsopoulos NM. Oral manifestations of systemic autoimmune and inflammatory diseases: diagnosis and clinical management. The journal of evidence-based dental practice. 2012 Sep;12(3 Suppl):265-82. doi: 10.1016/S1532-3382(12)70051-9
Pawelczyk-Madalińska M, Sadlak-Nowicka J, Miernik-Kunc W. [Clinical image of oral mucous membrane in rheumatoid arthritis patients]. Przeglad lekarski. 2006;63(5):253-6.
Moen K, Bertelsen LT, Hellem S, Jonsson R, Brun JG. Salivary gland and temporomandibular joint involvement in rheumatoid arthritis: relation to disease activity. Oral diseases. 2005 Jan;11(1):27-34. doi: 10.1111/j.1601-0825.2004.01054.x
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