The Effect of Eight Weeks of Endurance Training and Curcumin Supplementation on the Levels of Inflammatory Markers and Cardiopulmonary Function of Obese Girls with a History of Coronavirus Infection
Authors
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Sara Hamidizadeh
Department of Sport Sciences, Ilam University, Ilam, Iran.
https://orcid.org/0009-0006-2651-9670
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Nabi Shamsaei
Department of Sport Sciences, Ilam University, Ilam, Iran
https://orcid.org/0000-0003-0677-355X
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Vahid Kazemizadeh
Department of Sport Sciences, Razi University, Kermanshah, Iran.
https://orcid.org/0000-0002-5786-0904
DOI:
https://doi.org/10.22100/ijhs.v10i4.1141Keywords:
IL-6, TNF-a, Obesity, Physical activity, COVID-19Abstract
Background: This study aimed to investigate the discrete and combined effects of 8 weeks of endurance training and curcumin supplementation on the levels of inflammatory markers and pulmonary function in obese girls with a history of coronavirus infection.
Methods: This research was conducted by semi-experimental method and clinical trial in the form of pre-test and post-test. 40 obese women were selected randomly and allocated into 4 groups: exercise+curcumin supplement (Curcu+Exe), exercise+placebo (Exe), curcumin supplement (Curcu), and control (Control). The subjects in exercise groups participated in an eight-week aerobic exercise program. The subjects of the supplement groups took three to four capsules every day. The level of blood serum inflammatory indicators was measured using the ELISA kit. The pulmonary function indices were evaluated using a spirometer.
Results: The results of the present study showed that eight weeks of progressive endurance training along with curcumin supplementation in obese girls with a history of corona infection, led to a decrease in inflammatory indicators (IL-6 and TNF-a) and improved pulmonary function indicators in the experimental groups.
Conclusions: Curcumin supplementation along with progressive endurance exercises can lead to the improvement of inflammatory conditions and pulmonary function in obese girls with a history of corona disease. Therefore, these people can improve their body composition and general health through the combination of endurance activity and curcumin supplementation.
References
Powell-Wiley TM, Poirier P, Burke LE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation, 2021;143(21):e984-e1010. doi: 10.1161/CIR.0000000000000973
Finkelstein EA, Khavjou OA, Thompson H, Trogdon JG, Pan L, Sherry B, Dietz W. Obesity and severe obesity forecasts through 2030. Am J Prev Med, 2012;42(6):563-70. doi: 10.1016/j.amepre.2011.10.026
Länsitie M, Kangas M, Jokelainen J, Venojärvi M, Timonen M, Keinänen-Kiukaanniemi S, et al. Cardiovascular disease risk and all-cause mortality associated with accelerometer-measured physical activity and sedentary time - a prospective population-based study in older adults. BMC Geriatrics, 2022;22(1):729. doi: 10.1186/s12877-022-03414-8
Shi JJ. Fan Q Su, Yang Z. Cytokines and abnormal glucose and lipid metabolism. Frontiers in endocrinology, 2019;10:703. doi: 10.3389/fendo.2019.00703
Vinagre I, Sánchez-Quesada JL, Sánchez-Hernández J, Santos D, Ordoñez-Llanos J, De Leiva A, et al. Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of LDL subfraction phenotype. Cardiovasc Diabetol, 2014;13:34. doi: 10.1186/1475-2840-13-34
Leick L, Lindegaard B, Stensvold D, Plomgaard P, Saltin B, Pilegaard H. Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise. Obesity (Silver Spring), 2007;15(2):356-63. doi: 10.1038/oby.2007.528
Al-Mansoori L, Al-Jaber H, Prince MS, Elrayess MA. Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance. Inflammation, 2022;45(1):31-44. doi: 10.1007/s10753-021-01559-z
Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal, 2020. 10(2): p. 102-8. doi: 10.1016/j.jpha.2020.03.001
Hill AM, Coates AM, Buckley JD, Ross R, Thielecke F, Howe PR. Can EGCG reduce abdominal fat in obese subjects? J Am Coll Nutr, 2007;26(4):396s-402s. doi: 10.1080/07315724.2007.10719628
Mohammadzamani T, Kazemizadeh V, Babaei N, The Effect of Aerobic Activity along with Green Tea and Coffee Consumption on Fat Oxidation and Blood Pressure in Overweight Girls. J Isfahan Med School, 2023;41(714):234-42.
Di Meo F, Margarucci S, Galderisi U, Crispi S, Peluso G. Curcumin, Gut Microbiota, and Neuroprotection. Nutrients, 2019;11(10):2426. doi: 10.3390/nu11102426
Jagetia GC, Aggarwal BB. Spicing up" of the immune system by curcumin. J Clin Immunol, 2007;27(1):19-35. doi: 10.1007/s10875-006-9066-7
Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods, 2017;6(10):92. doi: 10.3390/foods6100092
Alsharif FJ, Almuhtadi YA. The Effect of Curcumin Supplementation on Anthropometric Measures among Overweight or Obese Adults. Nutrients, 2021;13(2):680. doi: 10.3390/nu13020680
Osali A. Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome. Diabetol Metab Syndr, 2020;12:26. doi: 10.1186/s13098-020-00532-4
Goldhammer E, Tanchilevitch A, Maor I, Beniamini Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol, 2005;100(1):93-9. doi: 10.1016/j.ijcard.2004.08.073
McFarlin BK, Venable AS, Henning AL, Sampson JN, Pennel K, Vingren JL, et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin, 2016;5:72-8. doi: 10.1016/j.bbacli.2016.02.003
Khosrojerdi A, Mashayekhi K, Zare Marzouni H. Curcumin (Extracted from Tumeric) and its Therapeutic Effects. Jorjani Biomed J, 2016;4(2):1-20.
Meng Z, Yan C, Deng Q, Gao DF, Niu XL. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacol Sin, 2013;34(7):901-11. doi: 10.1038/aps.2013.24
Yun JM, Jialal I, Devaraj S. Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. J Nutr Biochem, 2011;22(5):450-8. doi: 10.1016/j.jnutbio.2010.03.014
Villegas I, Sánchez-Fidalgo S, de la Lastra CA. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Mol Nutr Food Res, 2011;55(2):259-67. doi: 10.1002/mnfr.201000225
Hong J, Bose M, Ju J, Ryu JH, Chen X, Sang S, et al. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis, 2004;25(9):1671-9. doi: 10.1093/carcin/bgh165
Literat A, Su F, Norwicki M, Durand M, Ramanathan R, Jones CA, et al. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Life Sci, 2001;70(3):253-67. doi: 10.1016/S0024-3205(01)01398-4
Gu Y, Lee HM, Napolitano N, Clemens M, Zhang Y, Sorsa T, et al. 4-methoxycarbonyl curcumin: a unique inhibitor of both inflammatory mediators and periodontal inflammation. Mediators Inflamm, 2013;2013:329740. doi: 10.1155/2013/329740
Quintana-Mendias E, Rodríguez-Villalobos JM, Gastelum-Arellanez A, Cervantes N, Carrasco-Legleu CE, Espino-Solis GP. The Effect of Acute Physical Exercise on Natural Killer Cells Populations and Cytokine Levels in Healthy Women. Sports, 2023;11(10):189. doi: 10.3390/sports11100189
Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN, et al. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring), 2008;16(5):1033-8. doi: 10.1038/oby.2008.37
Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr, 2015;34(6):1101-8. doi: 10.1016/j.clnu.2014.12.019
Rawashdeh A, Alnawaiseh N. The effect of high-intensity aerobic exercise on the pulmonary function among inactive male individuals. Biomed Pharmaco J, 2018;11(2):735-41. doi: 10.13005/bpj/1427
Aweto HA, Aiyegbusi AI, Ugonabo AJ, Adeyemo TA. Effects of aerobic exercise on the pulmonary functions, respiratory symptoms and psychological status of people living with HIV. J res health sci, 2016;16(1):17.
Irandoust K. The effects of selected aerobic exercises on pulmonary functions of high school obese girls. Inter j sch health, 2015;2(4):32-6. doi: 10.17795/intjsh29288
Grisbrook TL, Wallman KE, Elliott CM, Wood FM, Edgar DW, Reid SL. The effect of exercise training on pulmonary function and aerobic capacity in adults with burn. Burns, 2012;38(4):607-13. doi: 10.1016/j.burns.2011.11.004
Park J, Han D. Effects of high intensity aerobic exercise on treadmill on maximum-expiratory lung capacity of elderly women. J Physic Therapy Sci, 2017;29(8):1454-7. doi: 10.1589/jpts.29.1454
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