Inferior Frontal-Occipital Fasciculus (IFOF) is the Main Neural Pathway in Psychotic Symptoms Induced by Methamphetamine Abuse: A Tract-based Spatial Statistics Study
Authors
-
Javad Sheikhi Koohsar
Center for Health-Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
https://orcid.org/0000-0003-2425-6265
-
Salman Safdari
Department of Radiology Technology, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
https://orcid.org/0000-0003-2779-0826
-
Milad Bazghale
Center for Health-Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
https://orcid.org/0000-0003-1255-2219
-
Sadegh Masjoodi
Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
https://orcid.org/0000-0002-5277-9453
-
Alireza Azizi
Center for Health-Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
https://orcid.org/0000-0001-6289-7579
-
Hamid Kalalian Moghadam
School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
https://orcid.org/0000-0002-8342-919X
-
Mohammad Niroumand Sarvandani
Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
https://orcid.org/0000-0001-9790-3908
DOI:
https://doi.org/10.22100/ijhs.v8i4.944Keywords:
Methamphetamine, psychotic symptoms, Tract-Based Spatial Statistics (TBSS), Inferior Frontal-Occipital Fasciculus (IFOF)Abstract
Background: Chronic methamphetamine abuse can lead to white matter changes and increased levels of psychotic symptoms. This study aimed to investigate which neural pathway is most associated with the psychological symptoms of chronic Methamphetamine abuse.
Methods: We recruited 42 chronic methamphetamine abuse subjects meeting DSM-5 criteria and 21 healthy controls. Psychotic signs were measured using the positive and negative syndrome scale (PANSS). We applied tract-based spatial statistics (TBSS) to investigate group differences in alteration DTI parameters and their association with psychotic symptoms.
Results: Chronic methamphetamine abuse group had significantly lower FA and higher AD, RD, and MD in a wide range of white matter mainly IFOF, and subjects in the methamphetamine abuse group had significantly higher PANSS total scores when compared to the control group.
Conclusions: Chronic methamphetamine abuse shows subtle patterns of impaired white matter integrity of distinct cerebral nerve pathways, mainly IFOF relative to controls. The results are further suggested that neuronal tract-based pathology plays the main role in psychotic symptoms in methamphetamine abuse disorders.
Keywords: Methamphetamine, psychotic symptoms, Tract-Based Spatial Statistics (TBSS), Inferior Frontal-Occipital Fasciculus (IFOF).
References
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20. Chen H-F, Huang L-L, Li H-Y, Qian Y, Yang D, Qing Z, et al. Microstructural disruption of the right inferior fronto-occipital and inferior longitudinal fasciculus contributes to WMH-related cognitive impairment. 2019;
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2. Rawson RA. Current research on the epidemiology, medical and psychiatric effects, and treatment of methamphetamine use. In: Journal of Food and Drug Analysis. 2013.
3. Voce A. The Profile and Structure of Psychotic Symptoms associated with Methamphetamine Use 2021. 2021;
4. Huang S, Yang W, Luo J, Yan C, Liu J, Hao W, et al. Article 452 1 (2020) White Matter Abnormalities Based on TBSS and Its Correlation With Impulsivity Behavior of Methamphetamine Addicts. Front. Psychiatry [Internet]. 2020;11:452. Available from: www.frontiersin.org
5. Ottino-González J, Uhlmann A, Hahn S, Cao Z, Cupertino RB, Schwab N, et al. White matter microstructure differences in individuals with dependence on cocaine, methamphetamine, and nicotine: Findings from the ENIGMA-Addiction working group. Drug Alcohol Depend. 2022 Jan 1;230:109185.
6. Brooks S, Cockcroft K, Schiöth HB. Methamphetamine Use Disorder: Structural and functional implications as shown by brain imaging studies. In: Psychobiological Issues in Substance Use and Misuse. Routledge; 2020. p. 105–24.
7. Conner AK, Briggs RG, Sali G, Rahimi M, Baker CM, Burks JD, et al. A Connectomic Atlas of the Human Cerebrum-Chapter 13: Tractography Description of the Inferior Fronto-Occipital Fasciculus. Oper Neurosurg (Hagerstown, Md). 2018;15(1): S436–43.
8. Jones DK, Catani M, Reeves SJ, Shergill SS, Mcguire P, Horsfield MA, et al. A Tractography Approach to Studying Fronto-Temporal Fasciculi in Schizophrenia andLate-Onsett Schizophrenia-like. Hum Brain Mapp. 2003;11(2002):10477–10477.
9. Surbeck W, Hänggi J, Scholtes F, Viher P V., Schmidt A, Stegmayer K, et al. Anatomical integrity within the inferior fronto-occipital fasciculus and semantic processing deficits in schizophrenia spectrum disorders. Schizophr Res. 2020 Apr 1;218:267–75.
10. Rigucci S, Rossi-Espagnet C, Ferracuti S, De Carolis A, Corigliano V, Carducci F, et al. Anatomical substrates of cognitive and clinical dimensions in first-episod schizophrenia. Acta Psychiatr Scand. 2013;128(4):261–70.
11. Surbeck W, Hänggi J, Scholtes F, Viher P V., Schmidt A, Stegmayer K, et al. Anatomical integrity within the inferior fronto-occipital fasciculus and semantic processing deficits in schizophrenia spectrum disorders. Schizophr Res [Internet]. 2020;218XXXXx):267–75. Available from: https://doi.org/10.1016/j.schres.2019.12.025
12. Cooper R. Diagnostic and Statistical Manual of Mental Disorders (DSM). Knowl Organ. 2017;
13. Fountoulakis KN, Dragioti E, Theofilidis AT, Wikilund T, Atmatzidis X, Nimatoudis I, et al. Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study. Int J Neuropsychopharmacol [Internet]. 2019;22(11):681–97. Available from: https://academic.oup.com/ijnp/article/22/11/681/5576002
14. Kochunov P, Elliot Hong L, Dennis EL, Morey RA, Tate DF, Wilde EA, et al. ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. Josselin Houenou. 2022;13:194–206.
15. Huang S, Yang W, Luo J, Yan C, Liu J. White Matter Abnormalities Based on TBSS and Its Correlation With Impulsivity Behavior of Methamphetamine Addicts. Front Psychiatry. 2020;11(May):1–9.
16. Oishi K, Faria A, Jiang H, Li X, Akhter K, Zhang J, et al. Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: Application to normal elderly and Alzheimer’s disease participants. Neuroimage [Internet]. 2009;46(2):486–99. Available from: http://dx.doi.org/10.1016/j.neuroimage.2009.01.002
17. Rollans C, Cummine J. One tract, two tracts,e old tract, new tract: A pilot study of the structural and functional differentiation of the inferior fronto-occipital fasciculus. J Neurolinguistics [Internet]. 2018;46(December 2017):122–37. Available from: https://doi.org/10.1016/j.jneuroling.2017.12.009
18. Kalaria RN. The pathology and pathophysiology of vascular dementia. Neuropharmacology [Internet]. 2018;134:226–39. Available from: https://doi.org/10.1016/j.neuropharm.2017.12.030
19. Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, et al. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. Journals Gerontol - Ser A Biol Sci Med Sci. 2014;69(11):1339–52.
20. Chen H-F, Huang L-L, Li H-Y, Qian Y, Yang D, Qing Z, et al. Microstructural disruption of the right inferior fronto-occipital and inferior longitudinal fasciculus contributes to WMH-related cognitive impairment. 2019;
21. Altieri R, Melcarne A, Junemann C, Zeppa P, Zenga F, Garbossa D, et al. Inferior Fronto-Occipital fascicle anatomy in brain tumor surgeries: From anatomy lab to surgical theater. J Clin Neurosci. 2019 Oct 1;68:290–4.
Published
2022-02-22
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How to Cite
Inferior Frontal-Occipital Fasciculus (IFOF) is the Main Neural Pathway in Psychotic Symptoms Induced by Methamphetamine Abuse: A Tract-based Spatial Statistics Study. (2022). International Journal of Health Studies (Undergoing Change to Shahroud Journal of Medical Sciences), 8(4), 35-39. https://doi.org/10.22100/ijhs.v8i4.944
