The Role of Pre-Pregnancy Body Mass Index (BMI) in Predicting Maternal Serum Leptin

  • Marzieh Faghani Aghoozi 1 1. Department of Midwifery, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Najmeh Tehranian 2 2. Department of Midwifery and Reproductive Health, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran.
  • Fahimeh Ramezani Tehrani 3 3. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Amir Hamta4 4 Pediatrics Clinical Research Development Center, Assistant Professor of biostatistcs, Department of Social Medicine, Faculty of Medical Sciences, Qom University of Medical Sciences, Qom, Iran.
  • Malihe Amreian5 5 Department of Midwifery, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Mahdieh Kiani 5 Department of Midwifery, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Mona Joz Mohtashami 6 Department of Anesthesiology, School of Allied Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Masoumeh Mirzamoradi 7 7 Department of obstetrics and Gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.

Abstract

Background: The key role of leptin is regulation of appetite and body lipid and pregnancy is a condition associated with overeating, reduction in heating and adaptation of lipid cells, culminating in increased body fat mass. So, this study was conducted to examine the relationship between changes in pre-pregnancy BMI and leptin.
Methods: This Longitudinal study was conducted on 45 women in the first trimester of pregnancy using a longitudinal approach and convenience sampling method in Tehran city in 2015. The mothers in terms of pre-pregnancy BMI were divided into two groups: group A (n=22 with normal BMI) and group B (n=23 with high BMI), with maternal serum leptin being taken in 6-12 weeks and 15-20 weeks of pregnancy and measured by enzyme-linked immunosorbent assay (ELISA). The statistical data were analyzed by SPSS V.21 using Kolmogorov Smirnov, independent t-test, two-sample Chi square, Mann-Whitney, Regression, Pearson and Landa tests with P.V<0.05.
Results: The mean age of mothers in the present study was 27.47±5.55 years with a minimum age of 19 and a maximum age of 37 years. The mean plasma leptin of the first and second trimesters of pregnancy was significantly higher in the high BMI group than in the normal group. The correlation showed that the first trimester leptin and changes in leptin levels of pregnancy with pre-pregnancy BMI were significantly higher in the normal group (P=0.04 and P=0.003).
Conclusions: BMI before and during pregnancy can be a predictor of maternal serum leptin in pregnancy weight gain.
 
Published
Sep 16, 2019
How to Cite
FAGHANI AGHOOZI 1, Marzieh et al. The Role of Pre-Pregnancy Body Mass Index (BMI) in Predicting Maternal Serum Leptin. International Journal of Health Studies, [S.l.], sep. 2019. ISSN 2423-6594. Available at: <http://ijhs.shmu.ac.ir/index.php/ijhs/article/view/438>. Date accessed: 16 oct. 2019. doi: http://dx.doi.org/10.22100/ijhs.v4i4.438.
Section
Articles

Keywords

Leptin, pregnancy, BMI.