Antibacterial and Anti-Adherent Activity of Great Mullein (Verbascum Thapsus L.) Ethanolic Extract on in Vitro Biofilm Formation of Three Oral Streptococci

Authors

  • Hamid Kalalian-Moghaddam1 1. Dept. of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Mehdi Mirzaii2 2. Dept. of Bacteriology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Mehdi Khaksari3 3. Dept. of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Mojgan Fazli4 4. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Fatemeh Rahimi5 5. Applied Agricultural Science Education Center of Shahroud, Shahroud, Iran.
  • Alidad Amiri Behzadi6* 6. Young Researchers and Elites Club , North Tehran Branch, Islamic Azad University, Tehran, Iran.

DOI:

https://doi.org/10.22100/ijhs.v1i2.64

Keywords:

Verbascum thapsus, Ethanol extract, Oral streptococci, Antimicrobial activity, Biofilm.

Abstract

Background: Verbascum thapsus (VT) is a medicinal plant that chemical constituents of it revealed the presence of biologically active compounds with antibacterial properties. The aim of the present study was to evaluate the antimicrobial and anti-adherent activities of ethanol extract of (VT) against of three oral streptococci in vitro.

Methods: In this study, biofilm formation of S. mutans 1683ATCC35.668, S. sanguinis 1449CIP53.15 and S. salivarius 1448
CIP55.128 with ethanol extract of VT was tested using Micro-dilution assay and microtitre plate assay.

Results: Results showed that the biofilm formation of three oral streptococci with ethanol extract (leaves and root) of VT was
significantly lower than that of the control group without ethanol extract of VT. Meanwhile, the reduction degree was correlated to the concentration of ethanol extract of VT positively.

Conclusions: These results suggest that antimicrobial activity of ethanol extract of VT against three oral streptococci. VT extracts have inhibitory effects on biofilm formation of oral streptococci as the reduction of bacterial growth and reduction of biofilm formation
ability.

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Published

2015-11-15

Issue

Volume 1, Issue 2, 2015

Section

Articles

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How to Cite

Antibacterial and Anti-Adherent Activity of Great Mullein (Verbascum Thapsus L.) Ethanolic Extract on in Vitro Biofilm Formation of Three Oral Streptococci. (2015). International Journal of Health Studies (Undergoing Change to Shahroud Journal of Medical Sciences), 1(2), Page: 34-37. https://doi.org/10.22100/ijhs.v1i2.64