The Effect of 6-Week Interval and Continuous Training with Zizphus Vulgaris Extract Supplementation on Hippocampus’s BDNF Male Wistar Rats

  • Azam Bagherinia 1 1. MSc in Exercise Physiology, Department of Sport Sciences, University of Sistan and Baluchestan, Zahedan, Iran.
  • Maryam Banparvari 2* 2.Assistant professor, Department of Sport Sciences, Faculty of Education and psychology ,University of Sistan and Baluchestan, Zahedan, Iran.
  • Mehdi Mogharnasi 3 3. Associate Professor, Department of Sport Sciences, University of Birjand, Birjand, Iran.
  • Hadi Sarir 4 4. Associate Professor, Department of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, Iran.
  • Aynollah Naderi 5 5. School of Sport Science, Shahrood University of Technology, Shahrood, Semnan, Iran.

Abstract

Background: The aim of the study was to compare the effect of 6-week interval and Continuous training with Zizphus Vulgaris Extract supplementation on the hippocampus’s BDNF male Wistar rats.
Methods: Among 36 male rats (250-350 gr), randomly after adjusting the body weight, 6 rats were separated as the control group. 30 rats were divided into 5 groups: Continuous group (n=6), Interval group (n=6), Continuous with Zizphus Vulgaris Extract group (n=6), Interval with Zizphus Vulgaris Extract group (n=6) and Zizphus Vulgaris Extract group (n=6). The training groups completed 8 weeks of the training program, 5 days/week according to protocol. The Endurance Continuous protocol includes running exercise on a treadmill for, 10 m/min, 10 min/day to up 16 m/min, 40 min/ day. Endurance Interval protocol includes running exercise on a treadmill for, 5*4 min, with intensity 10 m/min to up 23 m/min, 52 min/ day.  The Zizphus Vulgaris Extract group, every 6 weeks, each rat consumed 400 mg/kg.day and 1.5 mL. At the end of the intervention, the animals were euthanized and the hippocampus’s BDNF was measured. Data were analyzed using one way ANOVA tests (Pvalue<0.05).
Results: Interval with the Zizphus Vulgaris Extract group had significantly increased hippocampus’s BDNF compared to control and Zizphus Vulgaris Extract groups ( respectively p= 0.01, p= 0.02). Other comparisons were not significant.
 Conclusions: Interval with Zizphus Vulgaris Extract induce more effective favorable changes in the hippocampus’s BDNF in male rats. Likely, that be the best Strategy to prevent negative effects on the hippocampus’s BDNF decrease.
Keywords: Interval training, Continuous training, Zizphus Vulgaris extract supplementation, Hippocampus’s BDNF, male wistar rats.
Published
Sep 19, 2020
How to Cite
BAGHERINIA 1, Azam et al. The Effect of 6-Week Interval and Continuous Training with Zizphus Vulgaris Extract Supplementation on Hippocampus’s BDNF Male Wistar Rats. International Journal of Health Studies, [S.l.], sep. 2020. ISSN 2423-6594. Available at: <http://ijhs.shmu.ac.ir/index.php/ijhs/article/view/783>. Date accessed: 04 dec. 2020. doi: http://dx.doi.org/10.22100/ijhs.v6i4.783.
Section
Articles